827-829
| Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput
Judd Berman,
Kathy Halm,
Kim Adkison, and
Joel Shaffer
[Full Article -
PDF] |
830-832
| Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site
Thomas J. Tucker,
William C. Lumma,
Anne M. Mulichak,
Zhongguo Chen,
Adel M. Naylor-Olsen,
S. Dale Lewis,
Robert Lucas,
Roger M. Freidinger, and
Lawrence C. Kuo
[Full Article -
PDF] |
833-840
| GRID/GOLPE 3D Quantitative Structure-Activity Relationship Study on a Set of Benzamides and Naphthamides, with Affinity for the Dopamine D3 Receptor Subtype
Jonas Nilsson and
Håkan Wikström
, Age Smilde
, Shelly Glase and
Tom Pugsley
, Gabriele Cruciani,
Manuel Pastor, and
Sergio Clementi
[Full Article -
PDF] |
841-850
| Substituted Indole-2-carboxylates as in Vivo Potent Antagonists Acting as the Strychnine-Insensitive Glycine Binding Site
Romano Di Fabio,
Anna M. Capelli,
Nadia Conti,
Alfredo Cugola,
Daniele Donati,
Aldo Feriani,
Paola Gastaldi,
Giovanni Gaviraghi,
Cheryl T. Hewkin,
Fabrizio Micheli,
Andrea Missio,
Manolo Mugnaini,
Angelo Pecunioso,
Anna M. Quaglia,
Emiliangelo Ratti,
Luciana Rossi,
Giovanna Tedesco,
David G. Trist, and
Angelo Reggiani
[Full Article -
PDF] |
851-857
| 3'-Chloro-3-(diphenylmethoxy)tropane But Not 4'-Chloro-3- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile
Richard H. Kline,
Sari Izenwasser,
Jonathan L. Katz,
David B. Joseph,
Wayne D. Bowen, and
Amy Hauck Newman
[Full Article -
PDF] |
858-863
| Synthesis, Dopamine Transporter Affinity, Dopamine Uptake Inhibition, and Locomotor Stimulant Activity of 2-Substituted 3-Phenyltropane Derivatives
Lifen Xu,
Shreekrishna V. Kelkar,
Stacey A. Lomenzo,
Sari Izenwasser,
Jonathan L. Katz,
Richard H. Kline, and
Mark L. Trudell
[Full Article -
PDF] |
864-876
| Synthesis and Pharmacology of Novel Analogues of Oxytocin and Deaminooxytocin: Directed Methods for the Construction of Disulfide and Trisulfide Bridges in Peptides
Lin Chen,
Ivana Zoulíková,
Jiina Slaninová, and
George Barany
[Full Article -
PDF] |
877-884
| Biologically Active Conformer of the Effector Region of Human C5a and Modulatory Effects of N-Terminal Receptor Binding Determinants on Activity
Angela M. Finch,
Shawn M. Vogen,
Simon A. Sherman,
Leonid Kirnarsky,
Stephen M. Taylor, and
Sam D. Sanderson
[Full Article -
PDF] |
885-897
| Cyclic HIV-1 Protease Inhibitors Derived from Mannitol: Synthesis, Inhibitory Potencies, and Computational Predictions of Binding Affinities
Johan Hultén,
Nicholas M. Bonham,
Ulrika Nillroth,
Tomas Hansson,
Guido Zuccarello,
Abderrahim Bouzide,
Johan Åqvist,
Björn Classon,
U. Helena Danielson,
Anders Karlén,
Ingemar Kvarnström,
Bertil Samuelsson, and
Anders Hallberg
[Full Article -
PDF] |
898-902
| Unexpected Binding Mode of a Cyclic Sulfamide HIV-1 Protease Inhibitor
Kristina Bäckbro,
Seved Löwgren,
Katrin Österlund,
Johnson Atepo, and
Torsten Unge
, Johan Hultén,
Nicholas M. Bonham,
Wesley Schaal,
Anders Karlén, and
Anders Hallberg
[Full Article -
PDF] |
903-919
| Design, Synthesis, and Biological Activities of Four Angiotensin II Receptor Ligands with -Turn Mimetics Replacing Amino Acid Residues 3-5
Boris Schmidt,
Susanna Lindman,
Weimin Tong,
Gunnar Lindeberg,
Adolf Gogoll,
Zhennan Lai,
Madeleine Thörnwall,
Barbro Synnergren,
Annika Nilsson,
Christopher J. Welch,
Morgan Sohtell,
Christer Westerlund,
Fred Nyberg,
Anders Karlén, and
Anders Hallberg
[Full Article -
PDF] |
920-929
| HIV-1 Integrase Pharmacophore: Discovery of Inhibitors through Three-Dimensional Database Searching
Marc C. Nicklaus,
Nouri Neamati,
Huixiao Hong,
Abhijit Mazumder,
Sanjay Sunder,
Julie Chen,
George W. A. Milne, and
Yves Pommier
[Full Article -
PDF] |
930-936
| Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching
Huixiao Hong,
Nouri Neamati,
Shaomeng Wang,
Marc C. Nicklaus,
Abhijit Mazumder,
He Zhao,
Terrence R. Burke, Jr.,
Yves Pommier, and
George W. A. Milne
[Full Article -
PDF] |
937-941
| Hydrazide-Containing Inhibitors of HIV-1 Integrase
He Zhao,
Nouri Neamati,
Sanjay Sunder,
Huixiao Hong,
Shaomeng Wang,
George W. A. Milne,
Yves Pommier, and
Terrence R. Burke, Jr.
[Full Article -
PDF] |
942-951
| Depsides and Depsidones as Inhibitors of HIV-1 Integrase: Discovery of Novel Inhibitors through 3D Database Searching
Nouri Neamati,
Huixiao Hong,
Abhijit Mazumder,
Shaomeng Wang,
Sanjay Sunder,
Marc C. Nicklaus,
George W. A. Milne,
Bohumil Proksa, and
Yves Pommier
[Full Article -
PDF] |
952-960
| New Benzocycloalkylpiperazines, Potent and Selective 5-HT1A Receptor Ligands
Youssef El Ahmad,
Elisabeth Laurent,
Philippe Maillet,
Akram Talab,
Jean François Teste,
Raymond Dokhan,
Gilles Tran, and
Roland Ollivier
[Full Article -
PDF] |
961-966
| Antitumor Agents. 172. Synthesis and Biological Evaluation of Novel Deacetamidothiocolchicin-7-ols and Ester Analogs as Antitubulin Agents
Qian Shi,
Pascal Verdier-Pinard,
Arnold Brossi,
Ernest Hamel,
Andrew T. McPhail, and
Kuo-Hsiung Lee
[Full Article -
PDF] |
967-971
| Semisynthetic Derivatives of Purpuromycin as Potential Topical Agents for Vaginal Infections
Aldo Trani,
Clelia Dallanoce,
Gianbattista Panzone,
Franca Ripamonti,
Beth P. Goldstein, and
Romeo Ciabatti
[Full Article -
PDF] |
972-979
| Synthesis and Antitumor Activity of Duocarmycin Derivatives: A-Ring Pyrrole Compounds Bearing Cinnamoyl Groups
Satoru Nagamura,
Akira Asai,
Nobuyoshi Amishiro,
Eiji Kobayashi,
Katsushige Gomi, and
Hiromitsu Saito
[Full Article -
PDF] |
980-989
| Effect of Structural Modification of Enol-Carboxamide-Type Nonsteroidal Antiinflammatory Drugs on COX-2/COX-1 Selectivity
Edward S. Lazer,
Clara K. Miao,
Charles L. Cywin,
Ronald Sorcek,
Hin-Chor Wong,
Zhaoxing Meng,
Ian Potocki,
MaryAnn Hoermann,
Roger J. Snow,
Matt A. Tschantz,
Terence A. Kelly,
Daniel W. McNeil,
Simon J. Coutts,
Laurie Churchill,
Anne G. Graham,
Eva David,
Peter M. Grob,
Wolfhard Engel,
Hans Meier, and
Günter Trummlitz
[Full Article -
PDF] |
990-995
| Conformationally Constrained Deltorphin Analogs with 2-Aminotetralin-2-Carboxylic Acid in Position 3
Géza Tóth,
Zsuzsa Darula,
Antal Péter,
Ferenc Fülöp,
Dirk Tourwé,
Hendrika Jaspers,
Patricia Verheyden,
Zsolt Böcskey,
Zoltán Tóth, and
Anna Borsodi
[Full Article -
PDF] |
996-1004
| New Non-Peptide Endothelin-A Receptor Antagonists: Synthesis, Biological Properties, and Structure-Activity Relationships of 5-(Dimethylamino)-N-pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides
Robert H. Bradbury,
Colin Bath,
Roger J. Butlin,
Michael Dennis,
Christine Heys,
Sarah J. Hunt,
Roger James,
Andrew A. Mortlock,
Neil F. Sumner,
Eric K. Tang,
Berwick Telford,
Elaine Whiting, and
Campbell Wilson
[Full Article -
PDF] |
1005-1017
| Structural Analogues of the Calanolide Anti-HIV Agents. Modification of the trans-10,11-Dimethyldihydropyran-12-ol Ring (Ring C)
David E. Zembower,
Shuyuan Liao,
Michael T. Flavin,
Ze-Qi Xu,
Tracy L. Stup,
Robert W. Buckheit, Jr.,
Albert Khilevich,
Aye Aye Mar, and
Abram K. Sheinkman
[Full Article -
PDF] |
1018-1025
| Sulfonimidamide Analogs of Oncolytic Sulfonylureas,1
John E. Toth,
Gerald B. Grindey,
William J. Ehlhardt,
James E. Ray,
George B. Boder,
Jesse R. Bewley,
Kim K. Klingerman,
Susan B. Gates,
Sharon M. Rinzel,
Richard M. Schultz,
Leonard C. Weir, and
John F. Worzalla
[Full Article -
PDF] |
1026-1040
| Inhibition of Stromelysin-1 (MMP-3) by P1'-Biphenylylethyl Carboxyalkyl Dipeptides
Craig K. Esser,
Robert L. Bugianesi,
Charles G. Caldwell,
Kevin T. Chapman,
Philippe L. Durette,
Narindar N. Girotra,
Ihor E. Kopka,
Thomas J. Lanza,
Dorothy A. Levorse,
Malcolm MacCoss,
Karen A. Owens,
Mitree M. Ponpipom,
Joseph P. Simeone,
Richard K. Harrison,
Lisa Niedzwiecki,
Joseph W. Becker,
Alice I. Marcy,
Melinda G. Axel,
Amy J. Christen,
Joseph McDonnell,
Vernon L. Moore,
Julie M. Olszewski,
Cheryl Saphos,
Denise M. Visco,
Frank Shen,
Adria Colletti,
Philip A. Krieter, and
William K. Hagmann
[Full Article -
PDF] |
1041-1045
| Repromicin Derivatives with Potent Antibacterial Activity against Pasteurella multocida
James W. McFarland,
Scott J. Hecker,
Burton H. Jaynes,
Martin R. Jefson,
Kristin M. Lundy,
Chi B. Vu,
Edward A. Glazer,
Susan A. Froshauer,
Shigeru F. Hayashi,
Barbara J. Kamicker,
Catherine P. Reese, and
Julie A. Olson
[Full Article -
PDF] |
1046-1046
| PHARMACOKINETIC ANALYSIS: A Practical Approach By Peter I. D. Lee and Gordon L. Amidon. Technomic Publishing, Lancaster, PA. 1996. xiii + 548 pp. 15.5 × 23.5 cm. ISBN 1-56676-425-4. $159.95.
John J. Brennan
[Full Article -
PDF] |
1047-1047
| Comparative Molecular Field Analysis of Haptens Docked to the Multispecific Antibody IgE(Lb4)
Armin M. Gamper,
Rudolf H. Winger,
Klaus R. Liedl,
Christoph A. Sotriffer,
Janos M. Varga,
Romano T. Kroemer, and
Bernd M. Rode
[Full Article -
PDF] |
1048-1048
| N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP Potassium Channel Openers. Modifications on the Western Region
Cyrus J. Ohnmacht,
Keith Russell,
James R.
Empfield,
Cathy A. Frank,
Keith H. Gibson,
Daniel R. Mayhugh,
Frances M. McLaren,
Howard S. Shapiro,
Frederick J. Brown,
Diane A.
Trainor,
Christopher Ceccarelli,
Margaret M. Lin,
Brian B. Masek,
Janet M. Forst,
Robert J. Harris,
James M. Hulsizer,
Joseph J. Lewis,
Stuart M.
Silverman,
Reed W. Smith,
Paul J. Warwick,
Sen T. Kau,
Alexa L. Chun,
Thomas L. Grant,
Burton B. Howe,
Jack H. Li,
Shephali Trivedi,
Tracy J. Halterman,
Christopher Yochim,
Martin C. Dyroff,
M.Kirkland, and
Kathleen L.
Neilson
[Full Article - PDF] |